Year Publication
2013 Kuhn-Nentwig L, Sheynis T, Kolusheva S, Nentwig W, Jelinek R (2013) N-terminal aromatic residues closely impact the cytolytic activity of cupiennin 1a, a major spider venom peptide. Toxicon (in press)
  Kuhn-Nentwig L & Nentwig W (2013) The immune system of spiders. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg
  Kuhn-Nentwig L & Nentwig W (2013) The cytotoxic mode of action of the venom of Cupiennius salei (Ctenidae). In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg
  Nentwig W & Kuhn-Nentwig L (2013) Main components of spider venoms. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg
  Nentwig W & Kuhn-Nentwig L (2013) Spider venoms potentially lethal to humans. In: Nentwig W (ed) Spider ecophysiology. Springer, Heidelberg
2012
Kuhn-Nentwig L, Fedorova IM, Lüscher BP, Kopp LS, Trachsel C, Schaller J, Vu XL, Seebeck T, Streitberger K, Nentwig W, Sigel E & Magazanik, LG (2012) A Venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities. J Biol Chem 287: 25640-25649
  Trachsel C, Siegemund D, Kämpfer U, Kopp LS, Bühr C, Grossmann J, Lüthi C, Cunningham M, Nentwig W, Kuhn-Nentwig L, Schürch S & Schaller J (2012) Multicomponent venom of the spider Cupiennius salei: a bioanalytical investigation applying different strategies. FEBS J 279: 2683-2694
  Trachsel C, Widmer C, Kämpfer U, Bühr C, Baumann T, Kuhn-Nentwig L, Schürch S, Schaller J & Baumann U (2012) Structural and biochemical characterization of native and recombinant single insulin-like growth factor-binding domain protein (SIBD-1) from the Central American hunting spider Cupiennius salei (Ctenidae). Proteins 80: 2323-2329
2011 Kuhn-Nentwig L, Stöcklin R & Nentwig W (2011) Venom composition and strategies in spiders: is everything possible? Adv Insect Physiol 40: 1-86
  Kuhn-Nentwig L, Largiadèr CR, Streitberger K, Chandru S, Bauman T, Kämpfer U, Schaller J, Schürch S & Nentwig W (2011) Purification, cDNA 1 structure and biological significance of a single insulin-like growth factor-binding domain protein (SIBD-1) identified in the hemocytes of the spider Cupiennius salei. Insect Biochem Mol Biol 41: 891-901
  Kuhn-Nentwig L, Willems J, Seebeck T, Shalaby T, Kaiser M & Nentwig W (2011) Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells. Amino Acids 40: 69-76
2010 Baumann T, Kämpfer U, Schürch S, Schaller J, Largiadèr C, Nentwig W & Kuhn-Nentwig L (2010) Ctenidins: antimicrobial glycine-rich peptides from the hemocytes of the spider Cupiennius salei. Cell Mol Life Sci 67: 2787-2798
  Baumann T, Kuhn-Nentwig L, Largiadèr C & Nentwig W (2010) Expression of defensins in non-infected araneomorph spiders. Cell Mol Life Sci 67: 2643-2651
2009 Kuhn-Nentwig L (2009) Cytolytic and antimicrobial peptides in the venom of scorpions and spiders. In:  De Lima ME (ed) Animal toxins: state of the art. Perspectives in health and biotechnology. University of Minas Gerais Publishing, Belo Horizonte
  Kuhn-Nentwig L, Trachsel C & Nentwig W (2009) Spider venom and hemolymph derived cytolytic and antimicrobial peptides. In: Howl J (ed) Bioactive peptides. CRC Press, Boca Raton
2007 Pukala TL, Doyle JR, Llewellyn LE, Kuhn-Nentwig L, Apponyi MA, Separovic F & Bowie JH (2007) Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase. FEBS J 274: 1778-1784
  Pukala TL, Boland MP, Gehman JD, Kuhn-Nentwig L, Separovic F & Bowie JH (2007) Solution structure and interaction of cupiennin 1a, a spider venom peptide, with phospholipid bilayers. Biochemistry 46: 3576-3585
  Kuhn-Nentwig L, Kubista H & Nentwig W (2007) Spider venom: a rich source of highly active molecules. Chimia, 61: 588
  Kubista H, Mafra RA, Chong Y, Nicholson GM, Beirao PSL, Cruz JS, Boehm S, Nentwig W & Kuhn-Nentwig L (2007) CSTX-1, a toxin from the venom of the hunting spider Cupiennius salei, is a selective blocker of L-type calcium channels in mammalian neurons. Neuropharmacology 52: 1650-1662
2005 Wullschleger B; Nentwig W; Kuhn-Nentwig L (2005) Spider venom: enhancement of venom efficacy mediated by different synergistic strategies in Cupiennius salei .  J Exp Biol 208: 2115-2121
2004 Wullschleger B; Kuhn-Nentwig L; Tromp J; Kämpfer U, Schaller J, Nentwig W (2004) CSTX-13, a highly synergistically acting two-chain neurotoxic enhancer in the venom of the spider Cupiennius salei (Ctenidae). PNAS 101: 11251-11256

Kuhn-Nentwig L; Schaller J; Nentwig W (2004) Biochemistry, toxicology and ecology of the venom of the spider Cupiennius salei (Ctenidae). Toxicon 43: 543-553
2003 Kuhn-Nentwig L (2003) Antimicrobial and cytolytic peptides of venomous arthropods. Cell Mol Life Sc 60: 2651-2668
2002 Kuhn-Nentwig L; Dathe M; Walz A; Schaller J, Nentwig W (2002) Cupiennin 1d*: the cytolytic activity depends on the hydrophobic N-terminus and is modulated by the polar C-terminus. FEBS Lett 527: 193-198
  Wigger E; Kuhn-Nentwig L; Nentwig W (2002) The venom optimisation hypothesis: a spider injects large venom quantities only into difficult prey types. Toxicon  40: 749-752
  Kuhn-Nentwig L; Müller J; Schaller J; Walz A, Dathe M, Nentwig W (2002) Cupiennin 1, a new family of highly basic antimicrobial peptides in the venom of the spider Cupiennius salei (Ctenidae). J Biol Chem 227: 11208-1216
2001 Schaller J; Kampfer U; Schürch S; Kuhn-Nentwig  L, Haeberli  S, Nentwig  W (2001) CSTX-9, a toxic peptide from the spider Cupiennius salei: amino acid sequence, disulphide bridge pattern and comparison with other spider toxins containing the cystine knot structure. Cell Mol Life Sci 58: 1538-1545
  Schaller J; Kuhn-Nentwig L; Schürch S; Kämpfer U, Müller J, Nentwig W (2001) Neurotoxic peptides in the multicomponent venom of the spider Cupiennius salei - Part I. Primary structure of neurotoxic peptides in relation to their biological function. Chimia 55: 1058-1062
  Schürch S; Schaller J; Kämpfer U; Kuhn-Nentwig L, Nentwig W (2001) Neurotoxic peptides in the multicomponent venom of the spider Cupiennius salei - Part II. Elucidation of the disulphide-bridge pattern of the neurotoxic peptide CSTX-9 by tandem mass spectrometry. Chimia 55: 1063-1066
  Mafra RA, Kuhn-Nentwig L, Beirão PSL, Araújo DAM & Cruz JS (2001) Effect of CSTX-1, a toxin from Cupiennius salei spider, on L-type calcium currents. XVI FESBE Annual Meeting , Abstract #20.030, pg 237, 2001
2000 Kuhn-Nentwig L; Schaller J; Kämpfer U; Imboden H, Malli H, Nentwig W (2000) A lysine rich C-terminal tail is directly involved in the toxicity of CSTX-1, a neurotoxic peptide from the venom of the spider Cupiennius salei.  Arch Ins Biochem Physiol 44: 101-111
  Malli H; Kuhn-Nentwig L; Imboden H; Moon M-J, Wyler T (2000) Immunocytochemical localization and secretion process of the toxin CSTX-1 in the venom gland of the wandering spider Cupiennius salei (Araneae : Ctenidae). Cell Tissue Res 299: 417-426
  Haeberli S; Kuhn-Nentwig L; Schaller J; Nentwig W (2000) Characterisation of antibacterial activity of peptide isolated from the venom of the spider Cupiennius salei (Araneae : Ctenidae). Toxicon 38: 373-380
1999 Malli H; Kuhn-Nentwig L; Imboden H; Nentwig W (1999) Effects of size, motility and paralysation time of prey on the quantity of venom injected by the hunting spider Cupiennius salei . J Exp Biol 202: 2083-2089
1998 Malli H; Imboden H, Kuhn-Nentwig L (1998) Quantifying the venom dose of the spider Cupiennius salei using monoclonal antibodies. Toxicon 36: 1959-1969
  Kuhn-Nentwig L; Bücheler A; Studer A; Nentwig W (1998) Taurine and histamine: Low molecular compounds in prey hemolymph increase the killing power of spider venom. Naturwissenschaften 85: 136-138
  Kuhn-Nentwig L, Schaller J, Streb B & Kämpfer U (1998) CSTX-4, a novel bactericidal and insecticidal peptide in the venom of Cupiennius salei. 12th World Congress on Animal, Plant and Microbial Toxins, Cuernavaca, Mexico, USA, September 21-26, 1997. Toxicon 36: 1276-1277
  Nentwig W, Kuhn-Nentwig L, Schaller J & Kämpfer U (1998) Amino acid sequence of the toxic spider peptide CSTX-2 and its structural and physiological differences to CSTX-1. 12th World Congress on Animal, Plant and Microbial Toxins, Cuernavaca, Mexico, USA, September 21-26, 1997. Toxicon 36: 1276
1997 Kuhn Nentwig L, Nentwig W (1997) Venom of the hunting spider Cupiennius salei (Ctenidae). Toxicon 35: 813
1996 Kuhn-Nentwig L & Malli H (1996) Purification and comparison of two toxic peptides (CSTX-1 and CSTX-2) in the venom of Cupiennius salei  (Ctenidae). Revue Suisse de Zoologie, vol. hors série, 371-375
1995 Boevé JL, Kuhn-Nentwig L, Keller S, Nentwig W (1995) Quantity and quality of venom released by a spider (Cupiennius salei, Ctenidae), Toxicon 33: 1347-1357
1994 Kuhn-Nentwig L, Schaller J, Nentwig W (1994) Purification of toxic peptides and the amino acid sequence of CSTX-1 from the multicomponent venom of Cupiennius salei (Araneae, Ctenidae). Toxicon 32: 287-302
1993 Kuhn-Nentwig L & Nentwig W (1993) Zur Biochemie des Giftes von Cupiennius salei (Ctenidae). Bull Soc neuchatel Sci nat 116: 153-159
1990
Kadenbach B, Büge U, Hüther F-J, Thiel C, Droste M, Schlerf A, Schneyder B, Kuhn-Nentwig L & Müller-Höcker J (1990) Regulation of activity and tissue-specific expression of cytochrome c oxidase genes under normal and pathological conditions. In: Bioenergetics; Molecular Biology, Biochemistry and Pathology (C. Kim and T. Ozawa, eds.) Plenum Publ. Corp., New York, 399-412
1987 Kadenbach B, Kuhn-Nentwig L, Stroh A & Büge U (1987) Structure and regulatory function of cytochrome c oxidase isozymes. In: Biomembranes: Structure, Biogenesis and Transport. C. Rajamanickam, ed., Today + Tomorrow's Printers + Publishers, New Delhi, pp. 103-122
  Kadenbach B, Kuhn-Nentwig L & Büge U (1987) Evolution of a regulatory enzyme: Cytochrome c oxidase (complex IV). Curr Top Bioenerg 15: 113-161
1986 Kuhn-Nentwig L, Kadenbach B (1986) Isolation and characterization of human heart cytochrome C oxidase. J Bioenergetics Biomembranes 18: 307-314
  Kadenbach B, Stroh A, Ungibauer A, Kuhn-Nentwig L (1986) Isozymes of cytochrome C oxidase – characterization and isolation from different tissues.  Meth Enzymology 126: 32-45
  Kuhn-Nentwig L, Kadenbach B (1986) Orientation of rat-liver  cytochrome C oxidase subunits investigated with subunit-specific antisera. Eu J Biochem 153: 101-104
1985 Kuhn-Nentwig L, Kadenbach B (1985) Isolation and properties of cytochrome C oxidase from rat-liver and quantification of immunological differences between isozymes from various rat-tissues with subunit-specific antisera. Eu J Biochem 149: 147-158
  Kuhn-Nentwig L, Kadenbach B (1985) Immunological identification of 4 different polypeptides in subunit VII of mammalian cytochrome C oxidase. FEBS Lett 172: 189-192

Investigations into the venom and immune system of spiders.

Year Description
1981 Diploma in biology, Department of Biology, University of Marburg, Germany
1985 PhD thesis, Department of Chemistry, University of Marburg, Germany
Since 1990
Senior scientist, University of Bern